Hypothyroidism, referred to in Unani medicine as Qillat-e-Ifraz-e-GhuddeDarqiyya, is a common endocrine disorder affecting thyroid gland function. Classical Unani physicians have elaborated upon thyroid-related conditions in their texts, describing goitre-like presentations and their humoral bases. According to Unani principles, the normal temperament (Mizaj) of the thyroid gland is Harr (hot); in hypothyroidism, this becomes Su’-i-Mizaj Barid (abnormally cold temperament). The condition is classified as a Balghamai (phlegmatic) disease. In contemporary medicine, hypothyroidism denotes reduced production of thyroid hormones, with clinical features including weight gain, hair loss, lethargy, dry skin, voice change, and constipation. Subclinical hypothyroidism is characterised by an elevated Thyroid Stimulating Hormone (TSH) with normal Free T3 and Free T4 levels. The present case report documents the successful management of subclinical hypothyroidism in a 22-year-old woman using the Unani compound formulation JawarishJalinoose at a dose of 2 g twice daily on an empty stomach, administered over a period of two months. A significant reduction in TSH levels from 20.02 mIU/ml to 4.22 mIU/ml was observed, along with marked clinical improvement.