Volume 5 Issue 1 2026 – Acta Pharma Reports

Effect of Sub-Inhibitory Antibiotic Concentrations from Pharmaceutical Efluentson Bioilm-Mediated Resistance in Pseudomonas aeruginosa

Ayoade Babatunde Olanrewaju¹
Charles Chukwuma Obirinanwa²
Joy Chimuanya Nnanna³
Nathan Rimamsanati Yohanna^4,5
Moses Adondua Abah^4,5
Micheal Oladosu Abimbola^5,6

Introduction Pharmaceutical effluents have become important environmental sources of antibiotic contamination because manufacturing plants and related discharge streams can release active antimicrobial residues, resistant bacteria, and resistance genes into receiving waters, thereby creating pollution hotspots where selective pressure for antimicrobial resistance can persist beyond the point of drug production, as described by [1]. Unlike short-term … Read more

CRISPR-Cas13a Point-of-Care Assay for Multiplex Detection of Lassa, Ebola, and Marburg Viruses in Whole Blood: A Systematic Review

Nwachukwu Adaeze Cynthia¹
Ayoade Babatunde Olanrewaju²
Charles Chukwuma Obirinanwa³
Suraka Buhari⁴
Joy Chimuanya Nnanna⁵
Moses Adondua Abah^6,7
Micheal Oladosu Abimbola⁷

Introduction Ebola virus (EBOV) and Lassa virus (LASV) pose immediate, severe threats to human life and public health, as demonstrated by ongoing outbreaks of EBOV disease (EVD) in the Democratic Republic of the Congo (DRC) and Lassa fever (LF) in Nigeria. Despite their high morbidity and mortality, EVD and LF are difficult to diagnose because … Read more

Immunotherapy for Autoimmune Disorders: Current Status and Future Perspectives

Williams Chijindu Iheanacho¹
Temitope Olamide Akinmoye²
Charles Chukwuma Obirinanwa³
Moses Adondua Abah^4,5
Micheal Oladosu Abimbola^5,6
Iwumune Chinomso Kosarachi⁷

Introduction Autoimmunity arises when T cells, B cells, or both become inappropriately activated and cause damage to one or more organs [1]. Under normal conditions, the immune system distinguishes self-components from foreign pathogens through immune-tolerance mechanisms that eliminate or silence self-reactive lymphocytes [2]. However, genetic susceptibility and environmental influences can disrupt the balance between immune … Read more

Advances in Nanoparticle synthesis techniques and their use in controlled and targeted drug delivery

Vanshika Lohia
Priya Srivastava

1. Introduction “Nano” is a thousand millionth of a metre. The branch of nanotechnology is the name given to the science that studies structures and molecules on a nanoscale level that range from atoms to macromolecules [1] [2]. Nanotechnology works on the atomic, molecular, and sub-molecular level [3]. The properties of the nanoparticle and the bulk material shows … Read more

The Evolving Role of Warfarin in the Era of Direct Oral Anticoagulants for Deep Vein Thrombosis

Umra Baig¹
Ashiq Hussain Magrey¹
Arham Ali Khan²
Adila Zehra³

Introduction Deep vein thrombosis (DVT) is a major component of venous thromboembolism (VTE), which remains a major cause of cardiovascular morbidity and mortality worldwide. For a long time, oral anticoagulation therapy was based entirely on vitamin K antagonists (VKAs) such as warfarin [1]. Warfarin has repeatedly proven its strong clinical efficacy in preventing recurrence of … Read more

Applications of Pharmacogenomics in Personalized Drug Therapy and Precision Healthcare Management

Devendra Kumar Sahu

1. Introduction The effectiveness of drug therapy varies substantially among individuals due to differences in genetic makeup, environmental exposures, lifestyle factors, age, sex, and disease characteristics. Conventional therapeutic approaches typically rely on standardized treatment protocols that assume similar drug responses across patient populations. However, clinical observations have demonstrated that patients receiving identical medications often exhibit … Read more

Synthesis, Characterization, and Biological Evaluation of Novel N- (Substituted Aryl) Acryloyl Theophylline Derivatives as Potential Antimicrobial, Anti-Inflammatory and Anti-Asthmatic Agents

Valarmathy Joshua¹
L. Samuel Joshua¹
Sherlyn Joshua²
Vinolyn Joshua²

1. Introduction N- (Substituted Aryl) Acryloyl Theophylline Derivatives are a class of compounds that involve the combination of theophylline, a known methylxanthine derivative, with acryloyl groups and substituted aryl groups. These derivatives are of interest in medicinal chemistry due to their potential bioactivity, which could include stimulating effects on the central nervous system, bronchodilation (opening … Read more

Reflexology in Greek Medicine:Historical Roots, Philosophical Frameworks, and Contemporary Clinical Applications

Raziya Banu M¹
Yasmeen K ¹
MD Husaamuddin Sharief ²
Nizamudeen S ¹

1. INTRODUCTION Reflexology occupies a unique position in the landscape of complementary and alternative medicine (CAM), combining elements of manual therapy, neurophysiological theory, and ancient healing traditions. In modern clinical contexts, reflexology involves the systematic application of pressure to designated reflex points on the feet, hands, and ears, with the therapeutic premise that these points … Read more

Management of “Qillat-E-Ifraz-E-Ghudde Darqiyya” (Subclinical Hypothyroidism) Using Unani Medicines: A Case Report

Madiha Anjum M
Nizamudeen S
Parvez Ahmed V
Akram Basha J
Mohammed Ashraf Ali
Tasleem Banu E

INTRODUCTION: The term hypothyroidism is derived from the Greek words hypo- meaning “reduced,” thyreos meaning “defence,” and eidos meaning “form.” Primary hypothyroidism refers to hormonal inadequacy caused by intrinsic thyroid gland dysfunction, which disrupts the synthesis and secretion of thyroxine (T4) and triiodothyronine (T3). A decline in serum thyroid hormone concentration triggers compensatory hypersecretion of … Read more

Natural Gums Used as Binder in Sustained Release Preparation

Victor Olaolu Abisoye

Introduction The verifiable evolution of drug delivery systems highlights the progression from simple formulations to sophisticated, technology-driven approaches. Sustained release preparations offer numerous advantages over the conventional forms. The main objective of a sustained release dosage form is to maintain blood drug levels at a stable, non-toxic and therapeutically effective concentration over an extended period … Read more